Potassium tert-butoxide → 1-Bromo-4-(1-fluorovinyl)benzene
反応式
CC(C)([O-])C.[K+].[Br:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([F:17])[CH2:15]Br)=[CH:10][CH:9]=1>CCCCC>[Br:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])=[CH2:15])=[CH:10][CH:9]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
In several portions, 796 mg (7.09 mmol) of potassium tert-butoxide were added to a solution, cooled to 0° C., of 1.0 g (3.55 mmol) of 1-bromo-4-(2-bromo-1-fluoroethyl)benzene in 10 ml of pentane. The resulting suspension was stirred at 0° C. for 30 min and then at RT for 1 h. The solid was filtered off, and the filtrate was washed with saturated ammonium chloride solution, dried over magnesium sulphate and carefully concentrated under reduced pressure. This gave 0.61 g (85.6% of theory) of the title compound.
後処理
- waitat RT for 1 h
- filtrationThe solid was filtered off
- washthe filtrate was washed with saturated ammonium chloride solution
- dry with materialdried over magnesium sulphate
- concentrationcarefully concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-7aeda70cbee24d77bc2ac8c3abf47173
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09018258B2
反応ノート
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