Hydrochloric Acid → HCID 67170485、化合物

HRID 1475693ノート

反応式

HRID 1475693 の反応式
[CH3:1][O:2][C:3]([C:5]1([NH:12][C:13](=[O:26])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22]C(=O)C)[CH:15]=2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4].C(=O)([O-])[O-].[K+].[K+].Cl>CO>[CH3:1][O:2][C:3]([C:5]1([NH:12][C:13](=[O:26])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([OH:22])[CH:15]=2)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)=[O:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 866725641-(3-Acetoxy-4-methoxy-benzoylamino)-Cycloheptanecarboxylic Acid Methyl Ester

生成物 1

HCID 67170485HCID 67170485、化合物収率 72.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The compound of step 1 (10.6 g, 29.4 mmol) was dissolved in methanol (100 ml), potassium carbonate (812 mg, 5.88 mmol) was added and the mixture was stirred overnight at room temperature. An excess of 2 N hydrochloric acid was added, the methanol was evaporated in vacuo and the residue partitioned between EA and water. The aqueous phase was extracted with EA, the combined organic phases were dried over sodium sulfate and evaporated to dryness to give the title compound (6.81 g).

後処理

  1. customthe methanol was evaporated in vacuo
  2. customthe residue partitioned between EA and water
  3. extractionThe aqueous phase was extracted with EA
  4. dry with materialthe combined organic phases were dried over sodium sulfate
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-936a78f353bd4dae8f3da64994faea6f
出典データセット
uspto-grants-2015_04
特許番号
US09018383B2

反応ノート

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