Butyramide → HCID 178448470、化合物

HRID 1475825

反応式

HRID 1475825 の反応式
C(N)(=O)CCC.[OH:7][NH:8][C:9](=[O:40])[C@:10]([CH3:39])([S:35]([CH3:38])(=[O:37])=[O:36])[CH2:11][CH2:12][N:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][C@H:27]3[CH2:32][CH2:31][C@@H:30]([OH:33])[CH2:29][CH2:28]3)=[CH:21][CH:20]=2)=[CH:15][C:14]1=[O:34]>>[OH:7][NH:8][C:9](=[O:40])[C@:10]([CH3:39])([S:35]([CH3:38])(=[O:37])=[O:36])[CH2:11][CH2:12][N:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][C@H:27]3[CH2:28][CH2:29][C@H:30]([OH:33])[CH2:31][CH2:32]3)=[CH:21][CH:20]=2)=[CH:15][C:14]1=[O:34]

参加物

3

反応物 2

HCID 10927ButyramideHCID 178448469HCID 178448469、化合物

生成物 1

HCID 178448470HCID 178448470、化合物収率 83%

実験手順

The title compound (300 mg, 83%) was prepared from (2R)-2-methyl-2-(methylsulfonyl)-4-[2-oxo-4-(4-{[trans-4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl]methoxy}phenyl)pyridin-1(2H)-yl]-Netrahydro-2H-pyran-2-yloxy)butanamide (480 mg, 0.726 mmol) by a procedure analogous to that described for (2R)—N-hydroxy-4-[4-{4-[(cis-4-hydroxycyclohexyl)methoxy]phenyl}-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)butanamide Example 8, Step F. LCMS m/z 493.7 (M+1)1H NMR (400 MHz, DMSO-d6) δ ppm 0.92-1.23 (m, 4H) 1.54 (s, 3H) 1.58-1.72 (m, 1H) 1.81 (br. s., 4H) 2.06-2.21 (m, 1H) 2.41 (s, 1H) 3.08 (s, 3H) 3.25-3.41 (m, 1H) 3.74 (br. s., 1H) 3.80 (d, J=6.44 Hz, 2H) 3.98-4.17 (m, 1H) 6.48-6.71 (m, 2H) 6.85-7.06 (m, 2H) 7.52-7.78 (m, 3H) 11.15 (s, 1H)

出典と根拠

ORDレコード
ord-9741cbd005b548f3a4621702bdf22c4e
出典データセット
uspto-grants-2015_04
特許番号
US09018384B2

関連ノート

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