Hydrochloric Acid → HCID 67258916、化合物
反応式
[CH2:1]([C:3]1[O:4][C:5]([CH2:8][N:9]2[C:14]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[S:17][C:13]=3[C:12](=[O:24])[N:11]([CH:25]3[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]3)[C:10]2=[O:38])=[CH:6][N:7]=1)[CH3:2].[ClH:39]>O1CCOCC1>[ClH:39].[CH2:1]([C:3]1[O:4][C:5]([CH2:8][N:9]2[C:14]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[S:17][C:13]=3[C:12](=[O:24])[N:11]([CH:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[C:10]2=[O:38])=[CH:6][N:7]=1)[CH3:2]参加物
4
実験手順
tert-butyl 4-{1-[(2-ethyl-1,3-oxazol-5-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (120 mg; compound B9) is dissolved in a solution of hydrogen chloride in 1,4-dioxane (5 ml, 6.8 M). The solution is stirred for 0.5 h at RT. The resulting precipitate is filtered off, washed with diethyl ether and dried in vacuo to give the title compound as a solid.