Hydrogen Peroxide → 2-amino-N-(2-methoxyphenyl)-6-(4-nitrophenyl)sulfinyl-benzamide

HRID 1476707

反応式

HRID 1476707 の反応式
[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[C:15]([S:19][C:20]2[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][CH:21]=2)[C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH3:14])=[O:5].[OH:29]O>CO>[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[C:15]([S:19]([C:20]2[CH:21]=[CH:22][C:23]([N+:26]([O-:28])=[O:27])=[CH:24][CH:25]=2)=[O:29])[C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH3:14])=[O:5]

参加物

4

反応物 2

HCID 784Hydrogen PeroxideHCID 718115872-amino-N-(2-methoxyphenyl)-6-(4-nitrophenyl-thio)benzamide

生成物 1

HCID 1184832402-amino-N-(2-methoxyphenyl)-6-(4-nitrophenyl)sulfinyl-benzamide収率 44.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
66 °C

実験手順

Compound 25 (1.0 equiv.) was dissolved in CH3OH (30 mL) with a magnetic stirrer at RT, and 35% H2O2 (3.0 equiv.) was added slowly to this solution. This reaction mixture was heated in an oil bath at 66° C. and monitored using TLC. The reaction was quenched with MnO2 at RT. The mixture was filtered and the residue was washed with ethyl acetate (3×5 mL). The liquid layer was concentrated under reduced pressure and the oily residue was purified by silica gel column chromatography (1:4 v/v ethyl acetate/petroleum ether) to provide a yellow solid; 44.3% yield;

後処理

  1. customThe reaction was quenched with MnO2 at RT
  2. filtrationThe mixture was filtered
  3. washthe residue was washed with ethyl acetate (3×5 mL)
  4. concentrationThe liquid layer was concentrated under reduced pressure
  5. customthe oily residue was purified by silica gel column chromatography (1:4 v/v ethyl acetate/petroleum ether)
  6. customto provide a yellow solid

出典と根拠

ORDレコード
ord-68ff612d1b96417d9b4870621bb3ef95
出典データセット
uspto-grants-2016_08
特許番号
US09402819B2

関連ノート

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