Ammonia methanol → 7-Chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxamide

HRID 1476818ノート

反応式

HRID 1476818 の反応式
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:13]([O:15]CC)=O)[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[NH3:18].CO>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:13]([NH2:18])=[O:15])[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 21705897Ammonia methanolHCID 90386855Ethyl 7-chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

生成物 1

HCID 903871057-Chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxamide収率 38%

実験手順

Ethyl 7-chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxylate (580 mg, 2.30 mmol) was dissolved in NH3/MeOH(4.0M, 15 mL) and the reaction mixture was stirred at RT overnight. The solvent was removed in vacuo. The resulting residue was washed with petroleum ether and dried to give the title compound (200 mg, 38%). ESI-MS m/z [M+H]+223.1.

後処理

  1. customThe solvent was removed in vacuo
  2. washThe resulting residue was washed with petroleum ether
  3. customdried

出典と根拠

ORDレコード
ord-e9268d116d794627aca07daa61a2164a
出典データセット
uspto-grants-2016_08
特許番号
US09402841B2

反応ノート

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