Hydrochloric Acid → Hydrochloric Acid

反応式

[CH3:1][C@H:2]1[C@H:6]([O:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[C:10]([C:18]3[NH:22][C:21](=[O:23])[NH:20][N:19]=3)[N:9]=2)[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:31].O1CCOCC1>>[ClH:31].[CH3:1][C@@H:2]1[CH2:3][NH:4][CH2:5][C@H:6]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]([C:18]2[NH:22][C:21](=[O:23])[NH:20][N:19]=2)[N:9]=1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 136597019HCID 136597019、化合物

生成物 2

HCID 313Hydrochloric Acid

HCID 136596932HCID 136596932、化合物

実験手順

A mixture of tert-butyl trans-3-methyl-4-((3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)isoquinolin-1-yl)oxy)pyrrolidine-1-carboxylate (0.640 g, 1.555 mmol) and HCl in 1,4-dioxane (3.8 mL, 15.55 mmol) was stirred for 30 minutes, forming a mustard colored precipitate. The precipitate was filtered, washed with diethyl ether, and dried to give an HCl salt of the title compound (0.550 g, quantitative yield). 1H NMR (500 MHz, DMSO-d6) δ ppm 1.19 (d, 3H), 2.68-2.74 (m, 1H), 3.03 (dd, 1H), 3.27-3.60 (m, 3H), 3.86 (dd, 1H), 5.73-5.85 (m, 1H), 7.69 (t, 1H), 7.78-7.90 (m, 1H), 8.02 (s, 1H), 8.04 (d, 1H), 8.21-8.30 (m, 1H), 9.48 (br s, 1H), 9.67 (br s, 1H), 11.8 (s, 0.5H), 12.01 (s, 0.5H); ESI-MS m/z [M+H]+ 312.6.