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Z-Hyp(Tbu)-OH → (2S,4S)-4-amino-2-(5-phenyl-oxazol-2-yl)-pyrrolidine-1-carboxylic acid benzyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Z-Hyp(Tbu)-OH | HCID 6950951 | — |
| 反応物 | (2S,4S)-4-Amino-2-oxazol-2-yl-pyrrolidine-1-carboxylic acid benzyl ester | HCID 89768242 | — |
| 生成物 | (2S,4S)-4-amino-2-(5-phenyl-oxazol-2-yl)-pyrrolidine-1-carboxylic acid benzyl ester | HCID 89768393 | — |
反応手順
(2S,4S)-4-amino-2-(5-phenyl-oxazol-2-yl)-pyrrolidine-1-carboxylic acid benzyl ester was prepared from (2S,4R)-4-tert-butoxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester in a similar reaction sequence used in the preparation of (2S,4S)-4-amino-2-oxazol-2-yl-pyrrolidine-1-carboxylic acid benzyl ester. MS calcd. for C21H22N3O3 [(M+H)+] 364, obsd. 364.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09403805B2 |
| 出典データセット | uspto-grants-2016_08 |
| ORD ID | ord-ee40495a29e64e9fa21b624d0868538e |
| 出典メモ | uspto-grants-2016_08 |