3-Pyridinecarboxaldehyde → [3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-pyridin-3-ylmethyl-amine

反応式

[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)[CH2:11][NH:12][CH2:13][CH3:14])[CH:5]=[CH:4][N:3]=1.[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH:24]=O)[CH:19]=1>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)[CH2:11][N:12]([CH2:13][CH3:14])[CH2:24][C:20]2[CH:19]=[N:18][CH:23]=[CH:22][CH:21]=2)[CH:5]=[CH:4][N:3]=1

参加物

反応物 2

HCID 103713-Pyridinecarboxaldehyde

HCID 86603259[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amine

生成物 1

HCID 86603260[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-pyridin-3-ylmethyl-amine

実験手順

Intermediate 22 was coupled with pyridine-3-carboxaldehyde following procedure E. LC-MS showed the product had the expected M+H+ of 339.

出典と根拠

ORDレコード: ord-b79ffbcfe46d4fcb99be816f870ec14b
出典データセット: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07732444B2

反応ノート

読み込み中…