Benzoyl isothiocyanate → HCID 86688408、化合物
反応式
[C:1]([C:5]1[CH:9]=[C:8]([NH2:10])[N:7]([CH2:11][CH3:12])[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:13]([N:21]=[C:22]=[S:23])(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CC(C)=O>[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:22]([NH:21][C:13](=[O:20])[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[S:23])[N:7]([CH2:11][CH3:12])[N:6]=1)([CH3:4])([CH3:2])[CH3:3]参加物
4
反応条件
- 温度
- 60 °C
実験手順
To a solution of compound 23 (5.0 g, 29.9 mmol) in 40 mL of acetone at 0° C. was added dropwise benzoyl isothiocynate (4.88 g, 29.9 mmol). The reaction mixture was gradually warmed up and stirred in an oil bath of 60° C. until TLC indicated there was no starting material remained. Concentration of the reaction mixture on rotavapor gave a yellow solid, which was further triturated with ethyl ether to yield the desired product 24.