Triethylamine → HCID 118390102、化合物

HRID 1478012ノート

反応式

HRID 1478012 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([Cl:9])=[CH:4][N:3]=1.[NH2:10][CH:11]1[CH2:19][CH2:18][CH:17]2[CH:13]([CH2:14][N:15]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16]2)[CH2:12]1.CCN(CC)CC>CCO>[Cl:1][C:2]1[N:7]=[C:6]([NH:10][CH:11]2[CH2:19][CH2:18][CH:17]3[CH:13]([CH2:14][N:15]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16]3)[CH2:12]2)[C:5]([Cl:9])=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 2372592,4,5-TrichloropyrimidineHCID 83487964tert-butyl 5-amino-octahydro-1H-isoindole-2-carboxylate

生成物 1

HCID 118390102HCID 118390102、化合物収率 126.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 2,4,5-trichloropyrimidine (0.60 g, 3.27 mmol) and tert-butyl 5-aminohexahydro-1H-isoindole-2(3H)-carboxylate (2.79 g, 11.61 mmol) in EtOH (10 mL) was added Et3N (1.30 g, 12.84 mmol). After addition, the reaction mixture was stirred at rt overnight and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/5) to give the title compound as a pale yellow solid (1.60 g, 100%).

後処理

  1. additionAfter addition
  2. concentrationconcentrated in vacuo
  3. customThe residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/5)

出典と根拠

ORDレコード
ord-8d406dbfe6f844edb3022b74cba2c00c
出典データセット
uspto-grants-2016_08
特許番号
US09403801B2

反応ノート

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