Pivalaldehyde → 2,2-Dimethyl-5-hexen-3-ol

HRID 1478218ノート

反応式

HRID 1478218 の反応式
[CH3:1][C:2]([CH3:6])([CH3:5])[CH:3]=[O:4].[CH2:7]([Mg]Br)[CH:8]=[CH2:9]>C(OCC)C>[CH3:1][C:2]([CH3:6])([CH:3]([OH:4])[CH2:9][CH:8]=[CH2:7])[CH3:5]

参加物

4

反応物 2

HCID 12417PivalaldehydeHCID 178455850HCID 178455850、化合物

生成物 1

HCID 1405562,2-Dimethyl-5-hexen-3-ol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

To a solution of trimethylacetaldehyde (10.2 mL, 90.9 mmol) in diethyl ether (200 mL) at 0° C. was added allylmagnesium bromide (100 mL, 1M in ether). The reaction mixture was stirred at 0° C. for 1 hour. The resulting mixture was quenched with saturated ammonium chloride and extracted with diethyl ether. The organic extracts were washed with brine, dried over Na2SO4 and filtered. The solvent was carefully removed under reduced pressure to afford the title compound;

後処理

  1. customThe resulting mixture was quenched with saturated ammonium chloride
  2. extractionextracted with diethyl ether
  3. washThe organic extracts were washed with brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customThe solvent was carefully removed under reduced pressure

出典と根拠

ORDレコード
ord-915c196d2c344ef28620e5ea6f9851b6
出典データセット
uspto-grants-2016_08
特許番号
US09403810B2

反応ノート

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