(4-Chloro-3-methyl-2-pyridyl)-cyclopropyl-methanol → (4-Chloro-3-methyl-2-pyridyl)cyclopropylketone

HRID 1478299ノート

反応式

HRID 1478299 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]([CH:10]2[CH2:12][CH2:11]2)[OH:9])[C:3]=1[CH3:13]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([CH:10]2[CH2:11][CH2:12]2)=[O:9])[C:3]=1[CH3:13]

参加物

4

反応物 1

HCID 12071707(4-Chloro-3-methyl-2-pyridyl)-cyclopropyl-methanol

生成物 1

HCID 66980317(4-Chloro-3-methyl-2-pyridyl)cyclopropylketone収率 103.2%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

Manganese dioxide (1126 mg, 12.95 mmol) was added to a solution of (4-chloro-3-methylpyridin-2-yl)-cyclopropyl-methanol (250 mg, 1.214 mmol) in DCM (10 mL). The reaction mixture was stirred at room temperature for 45 h. The mixture was filtered over a porosity 4 filter. The filtrate was concentrated to dryness to yield white crystals (245 mg, 98%).

後処理

  1. filtrationThe mixture was filtered over a porosity 4
  2. filtrationfilter
  3. concentrationThe filtrate was concentrated to dryness

出典と根拠

ORDレコード
ord-c3e96b680f694686aa58563553c4de3e
出典データセット
uspto-grants-2016_08
特許番号
US09403818B2

反応ノート

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