Trimethyl orthoformate → 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine

反応式

[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)C=O)[CH:5]=[CH:4][N:3]=1.Cl.O1CCOCC1.[CH3:23][O:24][CH:25](OC)[O:26][CH3:27]>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[CH:10][CH:13]=[C:14]([CH:25]([O:26][CH3:27])[O:24][CH3:23])[CH:15]=2)[CH:5]=[CH:4][N:3]=1

参加物

反応物 3

HCID 9005Trimethyl orthoformate

HCID 204431481,4-Dioxane hydrochloride

HCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

生成物 1

HCID 866032612-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine

実験手順

Intermediate 1 (3.69 g) was refluxed for two hours in trimethylorthoformate containing 10 mL of 4N HCl/dioxane. The solvent was removed by rotary evaporation to give product, which showed the expected M+H+ of 265 by LC-MS.