化工社化工社 化学情報印刷レポート · 研究参考用
Tyramine → 4-{2-[4-(3-Dimethoxymethyl-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tyramine | HCID 5610 | — |
| 反応物 | 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine | HCID 86603261 | — |
| 生成物 | 4-{2-[4-(3-Dimethoxymethyl-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol | HCID 67045057 | 35% |
反応手順
Intermediate 26 was coupled with tyramine following procedure F. The product was purified by flash chromatography using 99:1 CH2Cl2:MeOH as eluent. Yield: 35%. LC-MS showed the product had the expected M+H+ of 366.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732444B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-571c36ad8b334d5587622f912b5c2a15 |
| 出典メモ | uspto-grants-2010_06 |