Sulfuric Acid → Ethyl 3-amino-6-bromopicolinate

HRID 1478541

反応式

HRID 1478541 の反応式
[NH2:1][C:2]1[C:3]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[Br:18]Br>O.CC(O)=O>[NH2:1][C:2]1[C:3]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:4][C:5]([Br:18])=[CH:6][CH:7]=1

参加物

6

反応物 3

HCID 1118Sulfuric AcidHCID 24408Bromine2 回HCID 565054Ethyl 3-aminopyridine-2-carboxylate

生成物 1

HCID 25137688Ethyl 3-amino-6-bromopicolinate

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒2 回HCID 962Water溶媒

実験手順

To a suspension of ethyl 3-aminopyridine-2-carboxylate (39.96 g, 241 mmol) in water (330 ml) was added H2SO4 (8 ml) and AcOH (16 ml). To this solution was added a solution of bromine in AcOH (84 ml) at ambient temperature under vigorous stirring so that the internal temperature remained around 25° C. After all bromine was added, stirring was continued for 1.5 h then the orange suspension was filtered giving ethyl 3-amino-6-bromo-pyridine-2-carboxylate.

後処理

  1. customremained around 25° C
  2. stirringstirring
  3. filtrationthe orange suspension was filtered

出典と根拠

ORDレコード
ord-be8199ea10ce466cab30937a4e63268c
出典データセット
uspto-grants-2016_08
特許番号
US09403845B2

関連ノート

読み込み中…