Dimethylmaleic anhydride → 4,5-Dimethylpyridazine-3,6-diol

HRID 1479982

反応式

HRID 1479982 の反応式
Cl.[NH2:2][NH2:3].[CH3:4][C:5]1=[C:6]([CH3:12])[C:7]([O:9][C:10]1=O)=[O:8]>O>[CH3:4][C:5]1[C:10](=[O:9])[NH:2][NH:3][C:7](=[O:8])[C:6]=1[CH3:12]

参加物

4

反応物 2

HCID 13010Dimethylmaleic anhydrideHCID 115031Hydrazinium chloride

生成物 1

HCID 2422804,5-Dimethylpyridazine-3,6-diol収率 99.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Hydrazine hydrochloride (58 g, 552 mmol) is dissolved in hot water (300 mL) and dimethyl maleic anhydride (58 g, 460 mmol) is added in portions and the suspension stirred at reflux for 16 h. The supension is cooled down to room temperature and the precipitate is filtered, washed with water and dried at 40° C. under vacuum to yield 4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (36) (64 g, 99%).

後処理

  1. temperatureat reflux for 16 h
  2. filtrationthe precipitate is filtered
  3. washwashed with water
  4. customdried at 40° C. under vacuum

出典と根拠

ORDレコード
ord-64e70e3e1f1f41f68cc34feb9f3895a4
出典データセット
uspto-grants-2016_08
特許番号
US09409871B2

関連ノート

読み込み中…