3-Benzyl-6-chloro-4,5-dimethylpyridazine → 3-Chloro-6-(4-fluorobenzyl)-4,5-dimethylpyridazine

反応式

[CH2:1]([C:8]1[N:9]=[N:10][C:11]([Cl:16])=[C:12]([CH3:15])[C:13]=1[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC1(Cl)C(C)=CN(Cl)N=C1.[Br-].[F:28]C1C=CC(C[Zn+])=CC=1>>[Cl:16][C:11]1[N:10]=[N:9][C:8]([CH2:1][C:2]2[CH:3]=[CH:4][C:5]([F:28])=[CH:6][CH:7]=2)=[C:13]([CH3:14])[C:12]=1[CH3:15]

参加物

反応物 3

HCID 591914873-Benzyl-6-chloro-4,5-dimethylpyridazine

HCID 866391094,5-Dimethyl-1,4-dichloro-pyridazine

HCID 178505763HCID 178505763、化合物

生成物 1

HCID 574310813-Chloro-6-(4-fluorobenzyl)-4,5-dimethylpyridazine

実験手順

Analogous to compound 42 above, 3-chloro-6-(4-fluoro-benzyl)-4,5-dimethyl-pyridazine is prepared from 4,5-dimethyl-1,4-dichloro-pyridazine and para-fluoro benzyl zinc bromide.

出典と根拠

ORDレコード: ord-257684ac2c9a430da9ee1801b583e811
出典データセット: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09409871B2

反応ノート

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