1-(Aminomethyl)cyclohexan-1-ol → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxy-cyclohexylmethyl)-amide

HRID 1480042

反応式

HRID 1480042 の反応式
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][CH2:17][C:18]1([OH:24])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[OH:24][C:18]1([CH2:17][NH:16][C:8]([C:5]2[CH:4]=[C:3]([O:11][CH2:12][CH:13]3[CH2:15][CH2:14]3)[C:2]([Cl:1])=[CH:7][N:6]=2)=[O:10])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

参加物

3

反応物 2

HCID 776141-(Aminomethyl)cyclohexan-1-olHCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

生成物 1

HCID 762819965-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxy-cyclohexylmethyl)-amide

実験手順

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and 1-(aminomethyl)-cyclohexanol (CAN 4000-72-0) as starting materials and isolated (19.2 mg, 57%) as white solid; MS (ESI, m/z): 339.1 (MH+).

後処理

  1. customisolated (19.2 mg, 57%) as white solid

出典と根拠

ORDレコード
ord-2fc57cd41f7646cd8178ede09e9a9eb9
出典データセット
uspto-grants-2016_08
特許番号
US09409866B2

関連ノート

読み込み中…