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HRID 1480050作成日：2026年10月27日

(S)-2-amino-2,3-dimethylbutan-1-ol → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-1-hydroxymethyl-1,2-dimethyl-propyl)-amide

https://huagongshe.com/reaction/1480050

反応式

関与物質

役割名称HCID仕込み量
反応物(S)-2-amino-2,3-dimethylbutan-1-olHCID 14919272—
反応物5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 90203638—
生成物5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-1-hydroxymethyl-1,2-dimethyl-propyl)-amideHCID 76282000—

反応手順

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and (2S)-2-amino-2,3-dimethyl-1-butanol (CAN 7533-40-6) as starting materials and isolated (21 mg, 73%) as colorless oil; MS (ESI, m/z): 327.2 (MH+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09409866B2
出典データセットuspto-grants-2016_08
ORD IDord-43712133c7234d2c86c0a9a2a12aecae
出典メモuspto-grants-2016_08