D-Valinol → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-2-methyl-propyl)-amide

HRID 1480051

反応式

HRID 1480051 の反応式
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][C@H:17]([CH:20]([CH3:22])[CH3:21])[CH2:18][OH:19]>>[OH:19][CH2:18][C@H:17]([NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[CH:20]([CH3:22])[CH3:21]

参加物

3

反応物 2

HCID 6950587D-ValinolHCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

生成物 1

HCID 762824835-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-2-methyl-propyl)-amide

実験手順

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and (2R)-2-amino-3-methyl-1-butanol (CAN 4276-09-9) as starting materials and isolated (51 mg, 54%) as colorless oil; MS (ESI, m/z): 313.1 (MH+).

後処理

  1. customisolated (51 mg, 54%) as colorless oil

出典と根拠

ORDレコード
ord-08fee72d8d5d4a3686d1a9c5f55b685f
出典データセット
uspto-grants-2016_08
特許番号
US09409866B2

関連ノート

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