3-Amino-4-methyl-pentan-1-ol → HCID 76282251、化合物

反応式

[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][CH:17]([CH:21]([CH3:23])[CH3:22])[CH2:18][CH2:19][OH:20]>>[OH:20][CH2:19][CH2:18][CH:17]([NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[CH:21]([CH3:23])[CH3:22]

参加物

反応物 2

HCID 170394293-Amino-4-methyl-pentan-1-ol

HCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

生成物 1

HCID 76282251HCID 76282251、化合物

実験手順

The title compound was synthesized in analogy to Example 12d, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and 3-amino-4-methyl-1-pentanol (CAN 26734-09-8) as starting materials and isolated (21 mg, 64%) as colorless oil; LC-MS (UV peak area, m/z) 100%, 327.1473 (MH+).

後処理

customisolated (21 mg, 64%) as colorless oil

出典と根拠

ORDレコード: ord-bab1927abdcb42fc9fc38e9033d3bf48
出典データセット: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09409866B2

反応ノート

読み込み中…

参加物