戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1480076作成日：2026年10月27日

(2R)-2-Amino-3,3-dimethylbutan-1-ol → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide

https://huagongshe.com/reaction/1480076

反応式

関与物質

役割名称HCID仕込み量
反応物(2R)-2-Amino-3,3-dimethylbutan-1-olHCID 6932847—
反応物5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 90203638—
生成物5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-2,2-dimethyl-propyl)-amideHCID 76283444—

反応手順

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and (2R)-2-amino-3,3-dimethyl-1-butanol (CAN 112245-09-7) as starting materials and isolated (80 mg, 80%) as colorless oil; LC-MS (UV peak area, m/z) 100%, 327.1476 (MH+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09409866B2
出典データセットuspto-grants-2016_08
ORD IDord-00014752e5cd4091b6963e4de7d701a2
出典メモuspto-grants-2016_08