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HRID 1480096作成日：2026年10月27日

2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amine → 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-amide

https://huagongshe.com/reaction/1480096

反応式

関与物質

役割名称HCID仕込み量
反応物2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amineHCID 25219911—
反応物5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 90203809—
生成物5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-amideHCID 76282721—

反応手順

The title compound was synthesized in analogy to Example 24d, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 2,2,2-Trifluoro-1-pyridin-2-yl-ethylamine (CAN 503173-14-6) as starting materials and isolated (17.2 mg, 29%) as colorless oil; MS (ESI, m/z): 392.5 (M+H+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09409866B2
出典データセットuspto-grants-2016_08
ORD IDord-906dd0849a1f46b285bae61897e1a53c
出典メモuspto-grants-2016_08