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HRID 1480112作成日：2026年10月26日

1-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1) → 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxy-cyclopentylmethyl)-amide

https://huagongshe.com/reaction/1480112

反応式

関与物質

役割名称HCID仕込み量
反応物1-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1)HCID 21109693—
反応物5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 90203809—
生成物5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxy-cyclopentylmethyl)-amideHCID 76284221—

反応手順

The title compound was synthesized in analogy to Example 54, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 1-(aminomethyl)cyclopentanol hydrochloride (CAN 76066-27-8) as starting materials and isolated (71 mg, 63%) as a white solid; MS (ESI, m/z): 331.0 (M+H+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09409866B2
出典データセットuspto-grants-2016_08
ORD IDord-a5afc7e1dceb466985df8d139186b165
出典メモuspto-grants-2016_08