2-(3-aminooxetan-3-yl)-N,N-dimethylacetamide → 5-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-dimethylcarbamoylmethyl-oxetan-3-yl)-amide
反応式
[Cl:1][C:2]1[C:3]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:17][C:18]1([CH2:22][C:23]([N:25]([CH3:27])[CH3:26])=[O:24])[CH2:21][O:20][CH2:19]1>>[CH3:27][N:25]([CH3:26])[C:23]([CH2:22][C:18]1([NH:17][C:8]([C:5]2[CH:4]=[C:3]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])[C:2]([Cl:1])=[CH:7][N:6]=2)=[O:10])[CH2:19][O:20][CH2:21]1)=[O:24]参加物
3
実験手順
The title compound was synthesized in analogy to Example 23b, using 5-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 24c) and 2-(3-Amino-oxetan-3-yl)-N,N-dimethyl-acetamide as starting materials and isolated (4 mg, 5%) as colorless oil; MS (ESI, m/z): 396.4 (M+H+).
後処理
- customisolated (4 mg, 5%) as colorless oil