(2S)-2-Amino-N,3,3-trimethylbutanamide → N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamide

HRID 1480241

反応式

HRID 1480241 の反応式
[F:1][C:2]1([C:6]2[C:7]([O:15][C@@H:16]([CH3:21])[C:17]([F:20])([F:19])[F:18])=[CH:8][C:9]([C:12](O)=[O:13])=[N:10][CH:11]=2)[CH2:5][O:4][CH2:3]1.[NH2:22][C@@H:23]([C:28]([CH3:31])([CH3:30])[CH3:29])[C:24]([NH:26][CH3:27])=[O:25]>>[CH3:29][C:28]([CH3:31])([CH3:30])[C@H:23]([NH:22][C:12]([C:9]1[CH:8]=[C:7]([O:15][C@@H:16]([CH3:21])[C:17]([F:19])([F:20])[F:18])[C:6]([C:2]2([F:1])[CH2:5][O:4][CH2:3]2)=[CH:11][N:10]=1)=[O:13])[C:24]([NH:26][CH3:27])=[O:25]

参加物

3

反応物 2

HCID 445856(2S)-2-Amino-N,3,3-trimethylbutanamideHCID 902149505-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid

生成物 1

HCID 118539962N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamide

実験手順

The title compound was synthesized in analogy to Example 112e, using 5-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid (example 142b) and (S)-2-Amino-3,3,N-trimethyl-butyramide (CAN 89226-12-0) as starting materials and isolated (40 mg, 57%); MS (ESI, m/z): 436.6 (M+H+).

後処理

  1. customisolated (40 mg, 57%)

出典と根拠

ORDレコード
ord-db0af5b42a084b04a54dd8e5c4e2f0b6
出典データセット
uspto-grants-2016_08
特許番号
US09409866B2

関連ノート

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