戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1480249作成日：2026年10月26日

1-Cyclopropyl-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-amine → N-[1-cyclopropyl-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-yl]-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamide

https://huagongshe.com/reaction/1480249

反応式

関与物質

役割名称HCID仕込み量
反応物1-Cyclopropyl-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-amineHCID 90204622—
反応物5-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acidHCID 90214950—
生成物N-[1-cyclopropyl-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-yl]-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamideHCID 90203518—

反応手順

The title compound was synthesized in analogy to Example 112e, using 5-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid (example 142b) and 1-cyclopropyl-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-amine (example 173b) as starting materials and isolated (70 mg, 46%); MS (ESI, m/z): 473.5 (M+H+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09409866B2
出典データセットuspto-grants-2016_08
ORD IDord-24e7e7dc2e914711b747f1c98e381b8a
出典メモuspto-grants-2016_08