化工社化工社 化学情報印刷レポート · 研究参考用
D-(-)-Tert-butyl tert-leucinate → tert-butyl 2-[[5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | D-(-)-Tert-butyl tert-leucinate | HCID 12490703 | — |
| 反応物 | 5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid | HCID 90204573 | — |
| 生成物 | tert-butyl 2-[[5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoate | HCID 90214929 | — |
反応手順
The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (Example 68a) and 2-Amino-3,3-dimethyl-butyric acid tert-butyl ester (CAN 99285-38-8) as starting materials and isolated (526 mg, 87%); MS (ESI, m/z): 445.6 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09409866B2 |
| 出典データセット | uspto-grants-2016_08 |
| ORD ID | ord-f41c6b010c7b4bada717b20b47f0778c |
| 出典メモ | uspto-grants-2016_08 |