Hydrochloric Acid → HCID 178520495、化合物
反応式
[OH:1][C:2]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([NH:11][CH2:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)=[O:10])[O:4][N:3]=1.Cl.O1CCOCC1>CCOC(C)=O>[OH:1][C:2]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([NH:11][CH2:12][CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)=[O:10])[O:4][N:3]=1参加物
5
実験手順
To tert-butyl 4-((3-(3-hydroxyisoxazol-5-yl)propanamido)methyl)piperidine-1-carboxylate (step 1) (539 mg, 1.525 mmol) in EtOAc (15 mL) was added 4N HCl in dioxane (15 ml, 60.0 mmol). The suspension was stirred at RT for 2 hrs and then concentrated under reduced pressure to give 3-(3-hydroxyisoxazol-5-yl)-N-(piperidin-4-ylmethyl)propanamide as a gum.
後処理
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-62ec94df059649fd9ab7a0f564d39f80
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409895B2
反応ノート
読み込み中…