Hydrochloric Acid → 3,5-Dichlorobenzyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate hydrochloride

HRID 1480456ノート

反応式

HRID 1480456 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[C:26]([Cl:28])[CH:27]=1)[CH2:5][O:6][C:7]([NH:9][CH:10]1[CH2:16][CH:15]2[N:17](C(OC(C)(C)C)=O)[CH:12]([CH2:13][CH2:14]2)[CH2:11]1)=[O:8].Cl>O1CCOCC1>[ClH:1].[CH:15]12[NH:17][CH:12]([CH2:13][CH2:14]1)[CH2:11][CH:10]([NH:9][C:7](=[O:8])[O:6][CH2:5][C:4]1[CH:3]=[C:2]([Cl:1])[CH:27]=[C:26]([Cl:28])[CH:25]=1)[CH2:16]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86722680HCID 86722680、化合物

生成物 1

HCID 867226813,5-Dichlorobenzyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

A reaction mixture comprising of tert-butyl 3-((((3,5-dichlorobenzyl)oxy)carbonyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate (388.3 mg, 0.904 mmol) in dioxane (5 mL) was treated with 4M HCl in dioxane (0.678 mL, 2.71 mmol) and stirred at room temperature for 3 hours. The resulting mixture concentrated under reduced pressure. No further purification was carried out and the material was taken on crude to the next step.

後処理

  1. concentrationThe resulting mixture concentrated under reduced pressure
  2. customNo further purification

出典と根拠

ORDレコード
ord-a7d1343e8cb847c39d82b31d49a4bb99
出典データセット
uspto-grants-2016_08
特許番号
US09409895B2

反応ノート

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