2-Bromo-1-mesitylethanone → 4-(2,4,6-Trimethylphenyl)-1,3-thiazol-2-amine

HRID 1480651

反応式

HRID 1480651 の反応式
Br[CH2:2][C:3]([C:5]1[C:10]([CH3:11])=[CH:9][C:8]([CH3:12])=[CH:7][C:6]=1[CH3:13])=O.[NH2:14][C:15]([NH2:17])=[S:16]>C(O)C>[C:6]1([CH3:13])[CH:7]=[C:8]([CH3:12])[CH:9]=[C:10]([CH3:11])[C:5]=1[C:3]1[N:14]=[C:15]([NH2:17])[S:16][CH:2]=1

参加物

4

反応物 2

HCID 2194802-Bromo-1-mesitylethanoneHCID 2723790Thiourea

生成物 1

HCID 6127164-(2,4,6-Trimethylphenyl)-1,3-thiazol-2-amine収率 107%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Bromo-1-mesitylethanone (2.43 g, 10.1 mmol) and thiourea (0.810 g, 10.6 mmol) were dissolved in 95% ethanol (20 mL). The reaction mixture was heated at reflux for 2.0 h. The solution was concentrated under reduced pressure, and the residue was recrystallized from 2-propanol to give the desired 4-mesitylthiazol-2-amine (2.36 g) as white solids: 1H NMR (500 MHz, CD3OD) δ 7.00 (2H, s), 6.67 (1H, s), 2.31 (3H, s), 2.19 (6H, s).

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 2.0 h
  3. concentrationThe solution was concentrated under reduced pressure
  4. customthe residue was recrystallized from 2-propanol

出典と根拠

ORDレコード
ord-d0c0452506cd43a0b24ababcd92fe3f8
出典データセット
uspto-grants-2016_08
特許番号
US09409902B2

関連ノート

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