Tert-butyl 2-cyano-2,2-dimethylacetate → Tert-butyl 3-amino-2,2-dimethylpropanoate
反応式
[C:1]([O:5][C:6](=[O:12])[C:7]([C:10]#[N:11])([CH3:9])[CH3:8])([CH3:4])([CH3:3])[CH3:2]>CO.[Ni]>[C:1]([O:5][C:6](=[O:12])[C:7]([CH3:9])([CH3:8])[CH2:10][NH2:11])([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
A mixture of cyano-dimethyl-acetic acid tert-butyl ester (5.3 g) and Raney Ni (2 mL in water) in MeOH (400 mL) was stirred at rt under H2 atmosphere (balloon) overnight. Then the reaction mixture was filtered over Celite pad, filtrate was concentrated to give the desired product (5 g). 1H NMR in CDCl3, δ in ppm: 2.8 (br, 2H), 1.45 (s, 9H), 1.17 (s, 6H).
後処理
- filtrationThen the reaction mixture was filtered over Celite pad, filtrate
- concentrationwas concentrated
出典と根拠
- ORDレコード
- ord-7419d1b1112e4b1f9e5e5ffa7d83e30d
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409892B2
反応ノート
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