Piperidine → (2S)-4-amino-2-(((tert-butoxy)carbonyl)amino)butanoic acid

HRID 1481020ノート

反応式

HRID 1481020 の反応式
[NH:1]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C@H:2]([C:23]([OH:25])=[O:24])[CH2:3][CH2:4][NH:5]C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.N1CCCCC1>CN(C=O)C>[NH2:5][CH2:4][CH2:3][C@H:2]([NH:1][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C:23]([OH:25])=[O:24]

参加物

4

反応物 2

HCID 8082PiperidineHCID 2755945Boc-Dab(Fmoc)-OH

生成物 1

HCID 7019666(2S)-4-amino-2-(((tert-butoxy)carbonyl)amino)butanoic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Boc-L-Dab(Fmoc)-OH (132 mg, 0.3 mmol, PepTech) and piperidine (0.2 mL, 2.02 mmol) were dissolved in DMF (1 mL). The resulting mixture was stirred at room temperature for 30 minutes. The volatiles were removed in vacuo and the residue was used directly in the subsequent step without further purification.

後処理

  1. customThe volatiles were removed in vacuo
  2. customthe residue was used directly in the subsequent step without further purification

出典と根拠

ORDレコード
ord-e6a05d0cb9c749679e54cfa24643962d
出典データセット
uspto-grants-2016_08
特許番号
US09409892B2

反応ノート

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