Piperidine → Boc-D-2,4-diaminobutyric acid
反応式
[NH:1]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C@@H:2]([C:23]([OH:25])=[O:24])[CH2:3][CH2:4][NH:5]C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.N1CCCCC1>CN(C=O)C>[NH2:5][CH2:4][CH2:3][C@@H:2]([NH:1][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C:23]([OH:25])=[O:24]参加物
4
実験手順
Boc-D-Dab(Fmoc)-OH (206 mg, 0.5 mmol, Oakwood Products) and piperidine (0.3 mL, 3.03 mmol) were dissolved in DMF (1.6 mL). The resulting mixture was stirred at room temperature for 30 minutes. The volatiles were removed in vacuo and the residue was used directly in the subsequent step without further purification.
後処理
- customThe volatiles were removed in vacuo
- customthe residue was used directly in the subsequent step without further purification
出典と根拠
- ORDレコード
- ord-65e57136971f48aa98e198a154513e6a
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409892B2
反応ノート
読み込み中…