HCID 58820945、化合物 → HCID 81947339、化合物
反応式
[C:1]([O:5][C:6](=[O:13])[C:7]([C:11]#[N:12])([CH3:10])[CH2:8][CH3:9])([CH3:4])([CH3:3])[CH3:2]>CCO.[Ni]>[C:1]([O:5][C:6](=[O:13])[C:7]([CH2:11][NH2:12])([CH3:10])[CH2:8][CH3:9])([CH3:2])([CH3:3])[CH3:4]参加物
4
実験手順
To a slurry of Raney-Ni (2.9 g, 50% in H2O, rinsed 3 times with EtOH before use) in EtOH (40 mL) was added 2-cyano-2-methyl-butyric acid tert-butyl ester (650 mg, 3.55 mmol). The resulting mixture was stirred under a hydrogen atmosphere at room temperature for 16 hours. The liquid was then carefully decanted into another flask and the metal was washed twice with EtOH. The combined EtOH solution was concentrated in vacuo to give the title compound in 600 mg, which was used directly in the subsequent step without further purification.
後処理
- customThe liquid was then carefully decanted into another flask
- washthe metal was washed twice with EtOH
- concentrationThe combined EtOH solution was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-d75e0caab90b4048af11b133e860af83
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409892B2
反応ノート
読み込み中…