Benzylurea → 7-(3-Benzyl-ureido)-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester

HRID 1481159ノート

反応式

HRID 1481159 の反応式
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11](Br)[CH:10]=2)=[O:5])[CH3:2].[CH2:18]([NH:25][C:26]([NH2:28])=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11]([NH:28][C:26]([NH:25][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:27])[CH:10]=2)=[O:5])[CH3:2]

参加物

3

反応物 2

HCID 10853BenzylureaHCID 89813095Ethyl 7-bromo-4-hydroxyisoquinoline-3-carboxylate

生成物 1

HCID 898129357-(3-Benzyl-ureido)-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester

実験手順

7-(3-Benzyl-ureido)-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester was prepared from 7-bromo-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester under conditions analogous to Example 116(a) using benzyl urea. The crude product was used in the following steps without purification.

後処理

  1. customThe crude product was used in the following steps without purification

出典と根拠

ORDレコード
ord-903b8f274c344b76a30020c6768cd8a8
出典データセット
uspto-grants-2016_08
特許番号
US09409892B2

反応ノート

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