Glycine → HCID 89815163、化合物
反応式
[C:1]1([CH3:20])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[O:7][C:8]1[CH:9]=[C:10]([C:17]([OH:19])=O)[C:11](=[CH:15][CH:16]=1)[C:12]([OH:14])=O.[NH2:21][CH2:22][C:23]([OH:25])=[O:24]>>[O:14]=[C:12]1[C:11]2[C:10](=[CH:9][C:8]([O:7][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=3[CH3:20])=[CH:16][CH:15]=2)[C:17](=[O:19])[N:21]1[CH2:22][C:23]([OH:25])=[O:24]参加物
3
反応条件
- 温度
- 230 °C
実験手順
A mixture of 4-(o-tolyloxy)phthalic acid (9.5 g, 35.0 mmol) and glycine (2.6 g, 35.0 mmol) was ground thoroughly in a mortar. The powder was then transferred to a flask and heated to 220-240° C. under high vacuum for 30 minutes. The reaction crude was cooled to room temperature to give the title compound in 10.2 g. 1H NMR (DMSO, 200 MHz): δ=7.89 (d, 1H, J=8.0 Hz), 7.42-7.08 (m, 6H), 4.27 (s, 2H), 2.14 (s, 3H).
後処理
- customThe powder was then transferred to a flask
- customThe reaction crude
- temperaturewas cooled to room temperature