HCID 89812992、化合物 → HCID 89813147、化合物
反応式
[C:1]([O:5][C:6](=[O:17])[CH:7]([C:15]#[N:16])[C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>[Ni].CO>[C:1]([O:5][C:6](=[O:17])[CH:7]([C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)[CH2:15][NH2:16])([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
Cyano-(4-fluoro-phenyl)-acetic acid tert-butyl ester (3.78 g) was mixed with Raney nickel (5 mL, 50% water) in MeOH (100 mL) and stirred under hydrogen balloon at rt overnight. The mixture was then filtered through Celite, concentrated to give crude, which was silica gel column purified to give 3-amino-2-(4-fluoro-phenyl)-propionic acid tert-butyl ester (1.3 g).
後処理
- filtrationThe mixture was then filtered through Celite
- concentrationconcentrated
- customto give crude, which
- custompurified
出典と根拠
- ORDレコード
- ord-0fce86e6bf4443e3aaa3408f06c5f8a7
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409892B2
反応ノート
読み込み中…