Hydrochloric Acid → Cyclopropanecarboxamide, 1-amino-2-ethenyl-N-[(1-methylcyclopropyl)sulfonyl]-, hydrochloride (1:1), (1R,2S)-
反応式
C(OC(=O)[NH:7][C@:8]1([C:13](=[O:22])[NH:14][S:15]([C:18]2([CH3:21])[CH2:20][CH2:19]2)(=[O:17])=[O:16])[CH2:10][C@H:9]1[CH:11]=[CH2:12])(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[NH2:7][C@:8]1([C:13]([NH:14][S:15]([C:18]2([CH3:21])[CH2:20][CH2:19]2)(=[O:17])=[O:16])=[O:22])[CH2:10][C@H:9]1[CH:11]=[CH2:12]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
A solution of tert-butyl((1R,2S)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-2-vinylcyclopropyl)carbamate (40 g, 116 mmol) in 4 N HCl in dioxane (400 mL) was stirred at room temperature for 1 h. The solvent was evaporated under reduced pressure and the residue was washed with diethyl ether to get crude compound (31 g, 95%). The crude compound was used without further purification. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.97-9.29 (m, 2H), 5.47-5.66 (m, 1H), 5.32-5.44 (m, 1H), 5.22 (dd, J=10.04, 1.51 Hz, 1H), 2.38 (s, 1H), 2.03 (s, 1H), 1.71 (d, J=3.51 Hz, 1H), 1.46-1.52 (m, 4H), 1.25-1.35 (m, 1H), 0.88-1.01 (m, 2H). MS: MS m/z 245.14 (M++1).