Lithium iodide → HCID 71282062、化合物

HRID 1481684ノート

反応式

HRID 1481684 の反応式
[CH2:1]([C:3]1[C:4]([OH:25])=[C:5]([C:21]([O:23]C)=[O:22])[C:6](=[O:20])[NH:7][C:8]=1[C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([CH3:19])[CH2:14][CH2:13][CH2:12]2)[CH3:2].[I-].[Li+]>CCOC(C)=O>[CH2:1]([C:3]1[C:4]([OH:25])=[C:5]([C:21]([OH:23])=[O:22])[C:6](=[O:20])[NH:7][C:8]=1[C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([CH3:19])[CH2:14][CH2:13][CH2:12]2)[CH3:2]

参加物

4

反応物 2

HCID 66321Lithium iodideHCID 71284563HCID 71284563、化合物

生成物 1

HCID 71282062HCID 71282062、化合物収率 61%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

反応条件

温度
65 °C

実験手順

To a suspension of methyl 5-ethyl-4-hydroxy-6-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)-2-oxo-1,2-dihydropyridine-3-carboxylate (34 mg, 0.1 mmol) in EtOAc (1 mL) was added lithium iodide (40 mg, ca. 0.3 mmol, 3.0 eq) at room temperature. The mixture was heated to 65° C. and stirred for 1 h. The reaction mixture was diluted by EtOAc (2 mL) then quenched with 1N HCl (0.5 mL). The precipitate was collected by filtration then washed with Et2O to afford the title compound as a yellow solid (20 mg, 0.061 mmol, 61%).

後処理

  1. customthen quenched with 1N HCl (0.5 mL)
  2. filtrationThe precipitate was collected by filtration
  3. washthen washed with Et2O

出典と根拠

ORDレコード
ord-d65a66f24a76462198d42ae14b4f433d
出典データセット
uspto-grants-2016_08
特許番号
US09409905B2

反応ノート

読み込み中…