Hydroxylamine → 5-Bromosalicylhydroxamic acid

HRID 1482862ノート

反応式

HRID 1482862 の反応式
[Br:1][C:2]1[CH:11]=[C:6]([C:7](OC)=[O:8])[C:5]([OH:12])=[CH:4][CH:3]=1.[NH2:13][OH:14]>O1CCOCC1.O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:12])=[C:6]([CH:11]=1)[C:7]([NH:13][OH:14])=[O:8]

参加物

5

反応物 2

HCID 787HydroxylamineHCID 77683Methyl 5-bromosalicylate

生成物 1

HCID 220465-Bromosalicylhydroxamic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

Methyl 5-bromosalicylate (5 g, 21.6 mmol) was dissolved in 90 mL 1,4-dioxane and 10 mL water. 10 mL 50% aqueous hydroxylamine solution was added and the mixture was stirred at ambient temperature for 24 hours. After concentrating the mixture under vacuum, water was added. The formed precipitate was filtered, washed with water and dried yielding 5-bromo-N,2-dihydroxybenzamide (4.12 g, 17.76 mmol) as off-white solid.

後処理

  1. concentrationAfter concentrating the mixture under vacuum, water
  2. additionwas added
  3. filtrationThe formed precipitate was filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-b8376e5484c44bdcb4cda9ecc9ea4db0
出典データセット
uspto-grants-2016_08
特許番号
US09416115B2

反応ノート

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