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Aminopyrazine → 4-(2-{4-[3-(Pyrazin-2-ylaminomethyl)-phenyl]-pyrimidin-2-ylamino}-ethyl)-phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aminopyrazine | HCID 78747 | — |
| 反応物 | 3-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzaldehyde | HCID 86603262 | — |
| 生成物 | 4-(2-{4-[3-(Pyrazin-2-ylaminomethyl)-phenyl]-pyrimidin-2-ylamino}-ethyl)-phenol | HCID 58603383 | — |
反応手順
Intermediate 28 was coupled with 2-aminopyrazine following procedure B. LC-MS showed the product had the expected M+H+ of 399. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) δ 8.3 (m, 2H), 8.1 (m, 1H), 8.0 (m, 3H), 7.7 (m, 2H), 7.5 (m, 3H), 7.1 (m, 2H), 6.7 (m, 2H), 4.6 (m, 2H), 3.6 (m, 2H), 2.8 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732444B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-3cb8c232762e4af394b1b080b292d32e |
| 出典メモ | uspto-grants-2010_06 |