Ammonia tetrahydrofuran → 4-(1,3-Dioxoisoindolin-2-yl)cyclohexane-1-sulfonamide

HRID 1483836ノート

反応式

HRID 1483836 の反応式
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH:12]1[CH2:17][CH2:16][CH:15]([S:18](Cl)(=[O:20])=[O:19])[CH2:14][CH2:13]1.[NH3:22].C1COCC1>>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH:12]1[CH2:17][CH2:16][CH:15]([S:18]([NH2:22])(=[O:20])=[O:19])[CH2:14][CH2:13]1

参加物

3

反応物 2

HCID 21982362Ammonia tetrahydrofuranHCID 893896834-(1,3-Dioxoisoindolin-2-yl)cyclohexane-1-sulfonyl chloride

生成物 1

HCID 712276614-(1,3-Dioxoisoindolin-2-yl)cyclohexane-1-sulfonamide収率 64%

実験手順

A mixture of 4-(1,3-dioxoisoindolin-2-yl)cyclohexane-1-sulfonyl chloride (5 g, 15.2 mmol) in NH3/THF (150 mL) was stirred at room temperature overnight. The mixture was concentrated in vacuo. The residue was dissolved into about 100 mL of hot water and the solid was filtered under hot condition. The filtrate was concentrated in vacuo to give 4-(1,3-dioxoisoindolin-2-yl)cyclohexane-1-sulfonamide (3 g, 64%) as an off-white solid.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. dissolutionThe residue was dissolved into about 100 mL of hot water
  3. filtrationthe solid was filtered under hot condition
  4. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-a6f1d9add9f54c7b9d6fa704e2e9d1d0
出典データセット
uspto-grants-2016_08
特許番号
US09416132B2

反応ノート

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