化工社化工社 化学情報印刷レポート · 研究参考用
N,N-dimethyl-4-nitrobenzenesulfonamide → Benzenesulfonamide, 4-amino-N,N-dimethyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-dimethyl-4-nitrobenzenesulfonamide | HCID 2747580 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Benzenesulfonamide, 4-amino-N,N-dimethyl- | HCID 74369 | 95% |
反応手順
Under H2, N,N-dimethyl-4-nitrobenzenesulfonamide (879 mg, 3.8 mmol, 1.0 equiv.) was catalytically hydrogenated in the presence of Pd/C (40 mg) in MeOH (25 mL). When no more H2 was consumed, the reaction mixture was filtered. The filtrate was concentrated and crystallized to afford compound 4-amino-N,N-dimethyl benzenesulfonamide (722 mg, 95%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09422271B2 |
| 出典データセット | uspto-grants-2016_08 |
| ORD ID | ord-516b0c9b1bff4851872f7983c660b89c |
| 出典メモ | uspto-grants-2016_08 |