Sodium sulfate decahydrate → Ctk0G8678

HRID 1485082

反応式

HRID 1485082 の反応式
[C:1]1([C@H:7]2[CH2:9][C@H:8]2[C:10](OCC)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Li+].[Al+3].[H-].[H-].[H-].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>C(OCC)C>[C:1]1([C@H:7]2[CH2:9][C@H:8]2[CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 62649Sodium sulfate decahydrateHCID 816743ethyl (1R,2S)-2-phenylcyclopropane-1-carboxylateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 11116214Ctk0G8678収率 102.9%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a solution in diethyl ether (12.0 mL) of the ethyl cis-2-phenylcyclopropanecarboxylate (1.51 g) obtained in step (1) above, a suspension of aluminum lithium hydride (393 mg) in diethyl ether (12.0 mL) was added at 0° C. After being brought to room temperature, the mixture was stirred for 2 hours. After adding sodium sulfate decahydrate at 0° C., the reaction mixture was brought to room temperature and stirred for an hour. After removing the insoluble matter by filtration, the filtrate was concentrated under reduced pressure to give (cis-2-phenylcyclopropyl)methanol as a colorless oil (1.21 g).

後処理

  1. additionwas added at 0° C
  2. customAfter being brought to room temperature
  3. customwas brought to room temperature
  4. stirringstirred for an hour
  5. customAfter removing the insoluble matter
  6. filtrationby filtration
  7. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-e69db3cab39648b5968832bc46602d20
出典データセット
uspto-grants-2016_08
特許番号
US09422240B2

関連ノート

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