Dimethylformamide → Ethyl 2-(3-((trimethylsilyl)ethynyl)pyrazin-2-yl)acetate

HRID 1485234ノート

反応式

HRID 1485234 の反応式
Cl[C:2]1[C:3]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:4][CH:5]=[CH:6][N:7]=1.CN(C=O)C.[CH3:19][Si:20]([C:23]#[CH:24])([CH3:22])[CH3:21]>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cu]I.C(N(CC)CC)C>[CH3:19][Si:20]([C:23]#[C:24][C:2]1[C:3]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:4][CH:5]=[CH:6][N:7]=1)([CH3:22])[CH3:21]

参加物

7

反応物 3

HCID 6228DimethylformamideHCID 66111TrimethylsilylacetyleneHCID 53419385Ethyl 2-(3-chloropyrazin-2-yl)acetate

生成物 1

HCID 68282873Ethyl 2-(3-((trimethylsilyl)ethynyl)pyrazin-2-yl)acetate収率 72%

試薬・触媒・溶媒 3

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 178418476HCID 178418476、化合物触媒HCID 8471Triethylamine溶媒

反応条件

温度
90 °C

実験手順

A mixture of the ethyl 2-(3-chloropyrazin-2-yl)acetate (I99) (0.410 g, 2.04 mmol), DMF (6 mL), triethylamine (2 mL), bis(triphenylphosphine)palladium(II) chloride (72 mg, 5 mol %) and copper(I) iodide (19 mg, 5 mol %) in a Schlenk tube was degassed with three vacuum/nitrogen cycles, then trimethylsilylacetylene (0.866 mL, 6.13 mmol) was added under nitrogen. The tube was flushed with nitrogen, sealed and heated to 90° C. After 18 hours the mixture was cooled and poured into water (50 mL). Saturated ammonium chloride (50 mL) was added, and the mixture was extracted with diethyl ether (3×100 mL). The combined ether phases were washed with brine, dried (sodium sulphate) and evaporated. The residue was chromatographed (40 g silica cartridge, 0-30% ethyl acetate/petroleum benzine 40-60° C.) to give the title compound (I100) (0.386 g, 72% yield) as a yellow oil; 1H NMR (400 MHz, CDCl3) δ 8.47-8.41 (m, 2H), 4.20 (q, J=7.1 Hz, 2H), 4.05 (s, 2H), 1.26 (t, J=7.1 Hz), 0.28 (s, 9H). LCMS Method C: rt 6.20 min; m/z 263.1 [M+H]+.

後処理

  1. customwas degassed with three vacuum/nitrogen cycles
  2. customThe tube was flushed with nitrogen
  3. customsealed
  4. temperatureAfter 18 hours the mixture was cooled
  5. additionpoured into water (50 mL)
  6. additionSaturated ammonium chloride (50 mL) was added
  7. extractionthe mixture was extracted with diethyl ether (3×100 mL)
  8. washThe combined ether phases were washed with brine
  9. dry with materialdried (sodium sulphate)
  10. customevaporated
  11. customThe residue was chromatographed (40 g silica cartridge, 0-30% ethyl acetate/petroleum benzine 40-60° C.)

出典と根拠

ORDレコード
ord-277bf1121e824984ae704b2925a35116
出典データセット
uspto-grants-2016_08
特許番号
US09421205B2

反応ノート

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