1,4-Dioxane hydrochloride → (4R)-4-Methoxy-L-proline methyl ester HCl

反応式

C(OC([N:8]1[CH2:12][C@H:11]([O:13][CH3:14])[CH2:10][C@H:9]1[C:15]([O:17][CH3:18])=[O:16])=O)(C)(C)C.[ClH:19].O1CCOCC1>>[ClH:19].[CH3:14][O:13][C@H:11]1[CH2:12][NH:8][C@H:9]([C:15]([O:17][CH3:18])=[O:16])[CH2:10]1

参加物

反応物 2

HCID 204431481,4-Dioxane hydrochloride

HCID 58984985(2S,4R)-1-tert-Butyl 2-methyl 4-methoxypyrrolidine-1,2-dicarboxylate

生成物 1

HCID 55254182(4R)-4-Methoxy-L-proline methyl ester HCl

実験手順

A solution of (2S,4R)-1-tertbutoxycarbonyl-2-methoxycarbonyl-4-methoxy pyrrolidine (9 g, 34.74 mmol) in 4 M HCl-dioxane (13 mL) was stirred at RT overnight. The reaction mixture was concentrated to dryness, washed with hexane followed by ether and dried under vacuum to afford (2S,4R)-methyl 4-methoxypyrrolidine-2-carboxylate hydrochloride (6 g).

後処理

concentrationThe reaction mixture was concentrated to dryness
washwashed with hexane
customdried under vacuum

出典と根拠

ORDレコード: ord-f62894f887324844a0d324f6b7b5f287
出典データセット: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09422267B2

反応ノート

読み込み中…

参加物