7-Bromo-2,4-dichlorothieno[3,2-d]pyrimidine → 7-Bromo-2-chlorothieno[3,2-d]pyrimidin-4-amine
反応式
[Br:1][C:2]1[C:6]2[N:7]=[C:8]([Cl:12])[N:9]=[C:10](Cl)[C:5]=2[S:4][CH:3]=1.C(O)(C)C.[NH3:17]>>[Br:1][C:2]1[C:6]2[N:7]=[C:8]([Cl:12])[N:9]=[C:10]([NH2:17])[C:5]=2[S:4][CH:3]=1参加物
3
反応条件
- 温度
- 80 °C
実験手順
7-Bromo-2,4-dichlorothieno[3,2-d]pyrimidine (3.0 g, 10.64 mmol) was added to a sealed reactor and 2.0 N ammonia isopropanol (26.6 mL, 53.2 mmol) was added thereto. The reaction mixture was stirred at 80° C. for 5 hours and then cooled to room temperature. The reaction mixture was added to ice water (100 mL). Thus prepared solid was filtered and dried by blowing nitrogen gas. The resultant target compound (2.1 g, 75% yield) was used in the following reaction without purification.
後処理
- temperaturecooled to room temperature
- filtrationThus prepared solid was filtered
- customdried
出典と根拠
- ORDレコード
- ord-a6b9a5b1fcff43afa9f3bf05afcfca12
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09422307B2
反応ノート
読み込み中…