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Hydrochloric Acid → (3S,4S)-3-amino-1-((3-cyclopropylquinolin-4-yl)methyl)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carbonitrile dihydrochloride

HRID 1486118
ノート
印刷プレビュー

反応式

HRID 1486118 の反応式
[C:1]([C:3]1[CH:37]=[CH:36][C:6]2[N:7]([CH2:22][C:23]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[N:26]=[CH:25][C:24]=3[CH:33]3[CH2:35][CH2:34]3)[C:8](=[O:21])[C@@H:9]([NH:13]C(=O)OC(C)(C)C)[C@H:10]([CH3:12])[NH:11][C:5]=2[CH:4]=1)#[N:2].[ClH:38]>O1CCOCC1.CCOCC>[ClH:38].[ClH:38].[NH2:13][C@@H:9]1[C:8](=[O:21])[N:7]([CH2:22][C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[N:26]=[CH:25][C:24]=2[CH:33]2[CH2:35][CH2:34]2)[C:6]2[CH:36]=[CH:37][C:3]([C:1]#[N:2])=[CH:4][C:5]=2[NH:11][C@H:10]1[CH3:12]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 131736782tert-butyl(3S,4S)-7-cyano-1-((3-cyclopropylquinolin-4-yl)methyl)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylcarbamate

生成物 1

HCID 90082583(3S,4S)-3-amino-1-((3-cyclopropylquinolin-4-yl)methyl)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carbonitrile dihydrochloride

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒
HCID 31275
1,4-Dioxane
溶媒

実験手順

A rt suspension of tert-butyl(3S,4S)-7-cyano-1-((3-cyclopropylquinolin-4-yl)methyl)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylcarbamate (134 mg, 269 μmol) in 4 M HCl in dioxane (1.35 ml) was stirred for 2.5 h. The reaction was diluted with Et2O and the solids were collected by vacuum filtration to provide (3S,4S)-3-amino-1-((3-cyclopropylquinolin-4-yl)methyl)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carbonitrile dihydrochloride (127 mg, quant.) as an off-white solid. MS m/z 398 (MH)+.

後処理

  1. filtrationthe solids were collected by vacuum filtration

出典と根拠

ORDレコード
ord-ee41c862928b4180b7ee4a29bca79928
出典データセット
uspto-grants-2016_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09422331B2

反応ノート

読み込み中…

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